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Thiabendazole

Thiabendazole

Item no.	HY-B0263-10mM
Manufacturer	MedChem Express
CASRN	148-79-8
Amount	10mM/1mL
Quantity options	10mM/1mL 1 g 500 mg 5 g
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.88
Formula	C10H7N3S
Citations	[1]Cha, H.J., et al., Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol, 2012. 10(8): p. e1001379. [2]Zhang, J., et al., Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie, 2013. 68(12): p. 962-8. [3]Budetić M, et al. Review of Characteristics and Analytical Methods for Determination of Thiabendazole. Molecules. 2023 May 6;28(9):3926. [4]Park J, et al. Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish. Environ Int. 2023 Jun;176:107973. [5]Elgebaly SA, et al. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Am J Pathol. 1984 May;115(2):204-11. [6]Motwadie ME, et al. Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats. Int Immunopharmacol. 2021 Sep;98:107902.
Smiles	C1(C2=CSC=N2)=NC3=CC=CC=C3N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tiabendazole; 2-(4-Thiazolyl)benzimidazole
Available
Product Description	Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	201.25
Clinical Information	Launched
Manufacturers Research Area	Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Target	Caspase; CDK; Interleukin Related; MDM-2/p53; Mitochondrial Metabolism; Parasite; VEGFR
Manufacturers Target	Caspase; CDK; Interleukin Related; MDM-2/p53; Mitochondrial Metabolism; Parasite; VEGFR
Isoform	Caspase 3; Caspase 9; CDK1; CDK2; IL-1; IL-10; IL-13; IL-6
Manufacturers Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-B0263-10mM-safety-datasheet.pdf