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Amphotericin B

Amphotericin B

Item no.	HY-B0221-500mg
Manufacturer	MedChem Express
CASRN	1397-89-3
Amount	500 mg
Quantity options	100 mg 10mM/1mL 1 g 500 mg
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules Neurodegeneration Markers;Research Area Neuroinflammation
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Formula	C47H73NO17
Citations	[1]Sau K, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.<br/>[2]Barwicz J, et al. The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. Chem Phys Lipids. 1997 Feb 28;85(2):145-55.<br/>[3]Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152(1):65-75.<br/>[4]Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9):2499-503.<br/>[5]Adams ML, et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4(3):750-7.
Smiles	C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1397-89-3
Available
Product Description	Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	924.08
Clinical Information	Launched
Manufacturers Research Area	Infection; Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	Antibiotic; Bacterial; Fungal; Parasite
Manufacturers Target	Antibiotic; Bacterial; Fungal; Parasite
Isoform	Leishmania; Plasmodium
Manufacturers Pathway	Anti-infection
Manufacturers Product type	Natural Products

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HY-B0221-500mg-safety-datasheet.pdf