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Orlistat

Orlistat

Item no.	HY-B0218-500mg
Manufacturer	MedChem Express
CASRN	96829-58-2
Amount	500 mg
Quantity options	100 mg 10mM/1mL 200 mg 500 mg
Category	Metabolism Cholesterol & Lipid Metabolism Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C29H53NO5
Citations	[1]Giorgia Cioccoloni, et al. Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro. Int J Oncol. 2015 Aug;47(2):764-72.<br/>[2]Zaidatul Akmal Othman, et al. Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model. Antioxidants (Basel). 2021 Feb 6;10(2):251.
Smiles	O=C1[C@@H](CCCCCC)[C@H](C[C@@H](OC([C@@H](N([H])C([H])=O)CC(C)C)=O)CCCCCCCCCCC)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tetrahydrolipstatin; Ro-18-0647
Available
Product Description	Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1]. Anti-atherosclerotic effect[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	495.73
Clinical Information	Launched
Manufacturers Research Area	Metabolic Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ mg/mL
Target	Apoptosis; Fatty Acid Synthase (FASN)
Manufacturers Target	Apoptosis; Fatty Acid Synthase (FASN)
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-B0218-500mg-safety-datasheet.pdf