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L-Ascorbic acid

L-Ascorbic acid

Item no.	HY-B0166-10mM
Manufacturer	MedChem Express
CASRN	50-81-7
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg
Category	Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules Acid Determination
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C6H8O6
Citations	[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35. [2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372. [5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2. Anim Biotechnol. 2024 Nov;35(1):2404043. Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. Antioxidants (Basel). 2024 May 27. Biochem Biophys Res Commun. 2024 Mar 15, 149770. Biomaterials. 2024 Aug 15:313:122756. Biomed Pharmacother. September 2022, 113558. Bioorg Chem. 2021, 105177. Bioorg Chem. 2024 Mar 5:146:107261. Biosci Rep. 2019 May 21;39(5):BSR20182137. Cancer Cell Int. 2024 May 31;24(1):192. Cancer Cell. 2024 Apr 8;42(4):682-700.e12. Cell Biol Toxicol. 2021 Jul 20. Cell Cycle. 2022 Nov 12;1-18. Cytotechnology. 02 October 2021. Drug Chem Toxicol. 2023 Feb 23;1-9. Eur J Med Chem. 2022 Jan 28;231:114151. Fitoterapia. 2021 Jun 30;104984. Food Funct. 2022 May 10;13(9):5089-5101. Free Radic Biol Med. 2020 Feb 1;147:220-230. Front Cell Dev Biol. 2022 Feb 10:10:810327. Genes. 2024 Sep 13. Int J Biol Macromol. 2023 Nov 17:127779. iScience. 2024 Feb 5;27(3):109111. IUBMB Life. 2024 Jul 16. J Biol Chem. 2023 Nov 15:105462. J Cell Mol Med. 2020 Apr;24(7):4212-4222. J Cell Physiol. 2024 Feb 3. J Mol Histol. 2024 May 27. J Nat Prod. 2022 Jul 7. J Neurosci Res. 2019 Dec;97(12):1689-1705. J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913. J Sex Med. 2018 Feb;15(2):136-147. Mol Biol Rep. 2024 Mar 14;51(1):421. Mol Med Rep. 2019 Dec; 20(6): 4933–4942. Nat Immunol. 2022 Dec 21. Nigerian Journal of Scientific Research. 18 (3): 2019. Oxid Med Cell Longev. 2022 Jan 27;2022:7502632. Redox Biol. 2022 Aug;54:102392. Research Square Print. 2022 Aug. Sci China Life Sci. 2018 Oct;61(10):1151-1167. Environ Toxicol. 2021 Apr;36(4):520-529. FASEB J. 2020 Sep;34(9):11474-11487. Hematol Oncol. 2024 Jul;42(4):e3295. J Afr Ass Physiol Sci. 7(1): 30-37, July 2019. Mil Med Res. 2020 Nov 1;7(1):52.
Smiles	OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-Ascorbate, Vitamin C
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species
Shipping Temperature	Room Temperature
Storage Conditions	RT, protect from light
Molecular Weight	176.12
Product Description	L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
Manufacturer - Research Area	Cancer; Metabolic Disease; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Isoform	Microbial Metabolite; T-type calcium channel
Clinical information	Launched

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HY-B0166-10mM-safety-datasheet.pdf