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L-Ascorbic acid

L-Ascorbic acid

Item no.	HY-B0166-10mM
Manufacturer	MedChem Express
CASRN	50-81-7
Amount	10mM/1mL
Quantity options	10mM/1mL 1 g 500 mg
Category	Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules Acid Determination
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C6H8O6
Citations	Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.<br>Biochem Biophys Res Commun. 2024 Mar 15, 149770.<br>Biomed Pharmacother. September 2022, 113558.<br>Bioorg Chem. 2021, 105177.<br>Bioorg Chem. 2024 Mar 5:146:107261.<br>Biosci Rep. 2019 May 21;39(5):BSR20182137.<br>Cancer Cell. 2024 Feb 23:S1535-6108(24)00046-1.<br>Cell Biol Toxicol. 2021 Jul 20.<br>Cell Cycle. 2022 Nov 12;1-18.<br>Cytotechnology. 02 October 2021.<br>Drug Chem Toxicol. 2023 Feb 23;1-9.<br>Eur J Med Chem. 2022 Jan 28;231:114151.<br>Fitoterapia. 2021 Jun 30;104984.<br>Food Funct. 2022 May 10;13(9):5089-5101.<br>Free Radic Biol Med. 2020 Feb 1;147:220-230.<br>Front Cell Dev Biol. 2022 Feb 10:10:810327.<br>Int J Biol Macromol. 2023 Nov 17:127779.<br>iScience. 2024 Feb 5;27(3):109111.<br>J Biol Chem. 2023 Nov 15:105462.<br>J Cell Mol Med. 2020 Apr;24(7):4212-4222.<br>J Cell Physiol. 2024 Feb 3.<br>J Nat Prod. 2022 Jul 7.<br>J Neurosci Res. 2019 Dec;97(12):1689-1705. <br>J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.<br>J Sex Med. 2018 Feb;15(2):136-147. <br>Mol Biol Rep. 2024 Mar 14;51(1):421.<br>Mol Med Rep. 2019 Dec; 20(6): 4933–4942.<br>Nat Immunol. 2022 Dec 21.<br>Nigerian Journal of Scientific Research. 18 (3): 2019.<br>Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.<br>Redox Biol. 2022 Aug;54:102392.<br>Research Square Print. 2022 Aug.<br>Sci China Life Sci. 2018 Oct;61(10):1151-1167.<br>Environ Toxicol. 2021 Apr;36(4):520-529.<br>FASEB J. 2020 Sep;34(9):11474-11487.<br>J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.<br>Mil Med Res. 2020 Nov 1;7(1):52.<br>[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.<br>[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.<br>[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.<br>[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.<br>[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.
Smiles	OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-Ascorbate; Vitamin C
Available
Product Description	L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	176.12
Clinical_Information	Launched
Manufacturers Research Area	Cancer; Metabolic Disease; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturers Target	Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species
Isoform	Human Endogenous Metabolite; Microbial Metabolite; T-type calcium channel
Pathway	Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

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HY-B0166-10mM-safety-datasheet.pdf