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Folinic acid (calcium salt pentahydrate)

Folinic acid (calcium salt pentahydrate)

Item no.	HY-B0080-200mg
Manufacturer	MedChem Express
CASRN	6035-45-6
Amount	200 mg
Quantity options	100 mg 10 mMx1 mL 200 mg 500 mg
Category	Food Safety Vitamines Neuroscience Neural Development Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Citations	J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15. bioRxiv. 2023 Feb 28. JAMA Oncol. 2022 Jan 1;8(1):e215445. Mol Oncol. 2020 Nov;14(11):2894-2919. NPJ Precis Oncol. 2023 Dec 8;7(1):128. Patent. US20230101335A1. Virology. 2023 Jun 21. EBioMedicine. 2024 Mar 13:102:105041. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Nat Commun. 2020 Apr 14;11(1):1792. [1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. [2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.
Smiles	O=CN1C(C2=O)=C(NC(N)=N2)NCC1CNC3=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C3.O.O.O.O.[Ca+2].O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Leucovorin (calcium salt pentahydrate)
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Antifolate; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	601.58
Product Description	Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : < 1 mg/mL\|H2O : 10 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Launched

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HY-B0080-200mg-safety-datasheet.pdf