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Vigabatrin (hydrochloride)

Vigabatrin (hydrochloride)

Item no.	HY-B0033-10mM
Manufacturer	MedChem Express
CASRN	1391054-02-6
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Formula	C6H12ClNO2
Citations	[1]Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [2]Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [3]Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7.
Smiles	C=CC(N)CCC(O)=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	γ-Vinyl-GABA (hydrochloride)
Available
Product Description	Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	165.62
Clinical Information	Launched
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 27.5 mg/mL (ultrasonic; warming)\|H2O : 33.33 mg/mL (ultrasonic)
Target	GABA Receptor
Manufacturers Target	GABA Receptor
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-B0033-10mM-safety-datasheet.pdf