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Flutamide

Flutamide

Item no.	HY-B0022-10mM
Manufacturer	MedChem Express
CASRN	13311-84-7
Amount	10mM/1mL
Quantity options	10mM/1mL 1 g 500 mg 5 g
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.90
Formula	C11H11F3N2O3
Citations	[1]Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70. [2]Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52. [3]Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24. [4]Rahimnia R, et al. The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study. Sci Rep. 2023 Nov 2;13(1):18940. [5]Lin CY, et al. Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):62-7. [6]Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8.
Smiles	CC(C)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SCH 13521
Available
Product Description	Flutamide is an Androgen Receptor antagonist with Ki=55 nM. Flutamide inhibits prostate cancer progression and has synergistic effects with Docetaxel (HY-B0011). Flutamide also has the potential to protect against hyperthermia-induced multiple organ dysfunction syndrome[1][2][3][4][5][6][7].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	276.21
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Target	Androgen Receptor
Manufacturers Target	Androgen Receptor
Manufacturers Pathway	Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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HY-B0022-10mM-safety-datasheet.pdf