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Doxifluridine

Doxifluridine

Item no.	HY-B0021-10mM
Manufacturer	MedChem Express
CASRN	05.09.3094
Amount	10mM/1mL
Quantity options	10mM/1mL 1 g 500 mg 5 g
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Gastric Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.91
Formula	C9H11FN2O5
Citations	[1]Naganuma Y, et al. Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. Cancer Sci. 2011 Aug;102(8):1545-52. [2] Berne M, et al. Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Cancer Invest. 1988;6(4):377-83. [3]Di Bartolomeo M, et al. Integrated treatment with doxifluridine and radiotherapy in recurrent or primary unresectable rectal cancer. A feasibility study. Tumori. 1999 May-Jun;85(3):211-3.
Smiles	O=C(N1)N([C@H]2[C@H](O)[C@H](O)[C@@H](C)O2)C=C(F)C1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR
Available
Product Description	Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	246.19
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMF : 100 mg/mL (ultrasonic)\|DMSO : ≥ 100 mg/mL\|H2O : 20 mg/mL (ultrasonic)
Target	Thymidylate Synthase
Manufacturers Target	Thymidylate Synthase
Manufacturers Pathway	Apoptosis
Manufacturers Product type	Reference compound

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HY-B0021-10mM-safety-datasheet.pdf