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Liothyronine (sodium)

Liothyronine (sodium)

Item no.	HY-A0070-10mM
Manufacturer	MedChem Express
CASRN	55-06-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.49
Formula	C15H11I3NNaO4
Citations	J Ethnopharmacol. 2022 Aug 11;115622.<br>JCI Insight. 2021 Jun 22;6(12):142838.<br>Sci Adv. 2024 Feb 9;10(6):eadk3931.<br>Acta Pharmacol Sin. 2024 May 24.<br>Adipocyte. 2022 Dec;11(1):84-98.<br>Am J Physiol Endocrinol Metab. 2024 Apr 3.<br>Cell Death Discov. 2022 Apr 30;8(1):236.<br>Cell Metab. 2023 Sep 7;S1550-4131(23)00304-2.<br>Cell Rep. 2024 Mar 18;43(3):113930.<br>Eur J Med Chem. 2024 Mar 20:269:116344.<br>Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.<br>J Med Chem. 2022 Jan 21.<br>J Nutr Biochem. 2020 Apr;78:108335.<br>Methods Mol Biol. 2023;2683:103-111.<br>Nat Commun. 2023 Jun 2;14(1):3208.<br>Patent. US20220389379A1.<br>[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.<br>[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.<br>[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.
Smiles	N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Triiodothyronine (sodium); 3,3',5-Triiodo-L-thyronine (sodium); T3 (sodium)
Available
Product Description	Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	672.96
Clinical_Information	Launched
Manufacturers Research Area	Cancer; Endocrinology
Solubility	DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Endogenous Metabolite; Thyroid Hormone Receptor
Isoform	Human Endogenous Metabolite
Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

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HY-A0070-10mM-safety-datasheet.pdf