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Trifluridine

Trifluridine

Item no.	HY-A0061-50mg
Manufacturer	MedChem Express
CASRN	70-00-8
Amount	50 mg
Quantity options	100 mg 10mM/1mL 200 mg 50 mg
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.98
Formula	C10H11F3N2O5
Citations	[1]Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62.<br/>[2]Jia HJ, et al. Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy. Biochem Biophys Res Commun. 2022 Jun 25;610:119-126.<br/>[3]Suzuki N,et al. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett. 2017 Jul;14(1):639-646.<br/>[4]Li J, et al. Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer. Am J Cancer Res. 2020 Feb 1;10(2):507-522.
Smiles	O[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Trifluorothymidine; 5-Trifluorothymidine; TFT
Available
Product Description	Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	296.20
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Apoptosis; Autophagy; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus; Thymidylate Synthase
Manufacturers Target	Apoptosis; Autophagy; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus; Thymidylate Synthase
Isoform	HSV-1; HSV-2
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-A0061-50mg-safety-datasheet.pdf