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Bosentan (hydrate)

Bosentan (hydrate)

Item no.	HY-A0013A-5g
Manufacturer	MedChem Express
CASRN	157212-55-0
Amount	5 g
Quantity options	100 mg 10mM/1mL 1 g 200 mg 500 mg 50 mg 5 g
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.85
Formula	C27H31N5O7S
Citations	[1]Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.<br/>[2]Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.<br/>[3]Iglarz M, et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9.
Smiles	O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=CC=CC=C3OC)(C4=CC=C(C(C)(C)C)C=C4)=O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	157212-55-0
Available
Product Description	Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	569.63
Clinical Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Target	Endothelin Receptor
Manufacturers Target	Endothelin Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-A0013A-5g-safety-datasheet.pdf