Item no. |
HY-A0008-10mg |
Manufacturer |
MedChem Express
|
CASRN |
36085-73-1 |
Amount |
10 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Clone |
N/A |
Specific against |
other |
Purity |
99.80 |
Formula |
C10H17Cl2N3S |
Citations |
[1]Ricci and Taira Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. (1999)32 29.<br/>[2]Eur J Pharmacol. 1997 May 1;325(2-3):137-44.<br/>[3]Kohno Y, Fukuzaki K, Kitahara K, Koja T.Anti-tremor activity of talipexole produced by selective dopamine D2 receptor stimulation in cynomolgus monkeys with unilateral lesions in the ventromedial tegmentum.Eur J Pharmacol. 1997 Jan 29;319(2-3):197-205.<br/>[4]Momiyama T, Sasa M, Takaori S.Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.Life Sci. 1991;49(7):535-43.<br/>[5]Nishikawa T, Yamada S, Tsuda A, Tanaka M, Koga I, Uchida Y.Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans.Clin Neuropharmacol. 1990 Jun;13(3):259-63.<br/>[6]Robertson, G.S., et al., In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J Pharmacol Exp Ther, 1993. 264(3): p. 1344-51. |
Smiles |
NC1=NC2=C(CCN(CC2)CC=C)S1.Cl.Cl |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
B-HT 920 (dihydrochloride) |
Available |
|
Product Description |
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neurodegeneration |
MolecularWeight |
282.23 |
Clinical Information |
Launched |
Manufacturers Research Area |
Neurological Disease; Endocrinology |
Solubility |
DMSO : 25 mg/mL (ultrasonic) |
Target |
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor |
Manufacturers Target |
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor |
Isoform |
5-HT3 Receptor; D2 Receptor; α adrenergic receptor |
Manufacturers Pathway |
GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.