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Tadalafil

Tadalafil

Item no.	HY-90009A-100mg
Manufacturer	MedChem Express
CASRN	171596-29-5
Amount	100 mg
Quantity options	100 mg 10mM/1mL 500mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C22H19N3O4
Citations	[1]Blount MA, et al. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency,specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol. 2004 Jul;66(1):144-52. [2]Yang Y, et al. Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies. Andrologia. 2013 Apr 14. [Epub ahead of print] [3]Mostafa ME, et al. Effect of Chronic Low-dose Tadalafil on Penile Cavernous Tissues in Diabetic Rats. Urology. 2013 Jun;81(6):1253-60.
Smiles	O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	IC-351
Available
Product Description	Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	389.40
Clinical Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : ≥ 52 mg/mL
Target	Apoptosis; Phosphodiesterase (PDE)
Manufacturers Target	Apoptosis; Phosphodiesterase (PDE)
Isoform	PDE5
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-90009A-100mg-safety-datasheet.pdf