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Enzalutamide

Enzalutamide

Item no.	HY-70002-1g
Manufacturer	MedChem Express
CASRN	915087-33-1
Amount	1 g
Quantity options	100 mg 10mM/1mL 10 mg 1 g 200 mg 2 g 500 mg 50 mg 5 g 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.96
Formula	C21H16F4N4O2S
Citations	[1]Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787-790.<br/>[2]Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 2010, 375(9724), 1437-1446.<br/>[3]Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305.<br/>[4]Kim TH, et al. Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats. Arch Pharm Res. 2015 Nov;38(11):2076-82.
Smiles	S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MDV3100
Available
Product Description	Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	464.44
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 50 mg/mL
Target	Androgen Receptor; Autophagy
Manufacturers Target	Androgen Receptor; Autophagy
Manufacturers Pathway	Autophagy; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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HY-70002-1g-safety-datasheet.pdf