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Deschloroclozapine

Deschloroclozapine

Item no.	HY-42110-10mM
Manufacturer	MedChem Express
CASRN	07.07.1977
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 g 50 mg 5g 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Formula	C18H20N4
Citations	Behav Brain Res. 2023 Sep 16;114674.<br/>bioRxiv. 2020 May 18. <br/>bioRxiv. 2023 Apr 24.<br/>bioRxiv. 2023 Dec 22.<br/>bioRxiv. 2023 Jun 24.<br/>bioRxiv. 2023 Jun 7.<br/>bioRxiv. 2023 Mar 6.<br/>bioRxiv. 2023 May 23.<br/>bioRxiv. 2023 Nov 17.<br/>bioRxiv. 2024 Feb 12.<br/>bioRxiv. 2024 Mar 12.<br/>bioRxiv. July 19, 2021.<br/>bioRxiv. November 25, 2021.<br/>Cell. 2023 Nov 22;186(24):5394-5410.e18.<br/>eNeuro. 2023 Oct 9:ENEURO.0162-23.2023.<br/>Eur J Neurosci. 2023 Sep 12.<br/>Front Aging Neurosci. 2023 Mar 23;15:1142055.<br/>iScience. 2021 Aug 30;24(9):103066.<br/>J Cereb Blood Flow Metab. 2021 Apr 14;271678X211007949.<br/>Nat Commun. 2022 Apr 25;13(1):2233.<br/>Nat Commun. 2022 Nov 4;13(1):6662.<br/>Nat Commun. 2023 Feb 24;14(1):1066.<br/>Nat Commun. 2023 Feb 28;14(1):971.<br/>Nat Commun. 2023 Jul 24;14(1):4456.<br/>Nat Commun. 2023 Oct 24;14(1):6758.<br/>Nat Neurosci. 2020 Sep;23(9):1157-1167.<br/>Neuromethods. 2023 Feb 7.<br/>Neuron. 2021 Oct 20;109(20):3312-3322.e5.<br/>Neuron. 2022 Jan 28;S0896-6273(22)00047-2.<br/>Neuropharmacology. 2023 May 8;109576.<br/>Neuropsychopharmacology. 2020 Oct;45(11):1793-1798.<br/>Patent. US20210275696A1.<br/>Research Square Preprint. 2023 Jul 24.<br/>Research Square Print. 2023 Mar 27.<br/>The University of Chicago. 2023 Dec.<br/>[1]Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475.<br/>[2]Hu F, et al. <sup>18</sup>F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047.<br/>[3]Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798.
Smiles	CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	07.07.1977
Available
Product Description	Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	292.38
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	mAChR
Manufacturers Target	mAChR
Isoform	mAChR3; mAChR4
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-42110-10mM-safety-datasheet.pdf