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Xanthotoxol

Xanthotoxol

Item no.	HY-30152-100mg
Manufacturer	MedChem Express
CASRN	2009-24-7
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.75
Formula	C11H6O4
Citations	[1]Ma Z, et al. Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.<br/>[2]Ma Z, et al. Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.<br/>[3]He W, et al. Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. Cell Mol Neurobiol. 2013 Jul;33(5):715-22.<br/>[4]Lee Y, et al. Anti-Inflammatory Effects of Psoralen Derivatives on RAW264.7 Cells via Regulation of the NF-κB and MAPK Signaling Pathways. Int J Mol Sci. 2022 May 22;23(10):5813.
Smiles	O=C1OC(C(C=C1)=C2)=C(O)C3=C2C=CO3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	8-Hydroxypsoralen
Available
Product Description	Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	202.16
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	5-HT Receptor; Endogenous Metabolite; Reactive Oxygen Species
Manufacturers Target	5-HT Receptor; Endogenous Metabolite; Reactive Oxygen Species
Isoform	5-HT Receptor; Human Endogenous Metabolite
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Manufacturers Product type	Natural Products

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HY-30152-100mg-safety-datasheet.pdf