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N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin

Item no.	HY-19791-5mg
Manufacturer	MedChem Express
CASRN	108212-76-6
Amount	5 mg
Quantity options	10mM*1 mL 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.39
Formula	C57H76IN3O22S4
Citations	[1]K C Nicolaou, et al. Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118.<br/>[2]Breanna S Vollmar, et al. Calicheamicin Antibody-Drug Conjugates with Improved Properties. Mol Cancer Ther. 2021 Jun;20(6):1112-1120.
Smiles	O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSSC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin
Available
Product Description	N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1410.39
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	ADC Cytotoxin; Antibiotic; Bacterial; DNA/RNA Synthesis
Manufacturers Target	ADC Cytotoxin; Antibiotic; Bacterial; DNA/RNA Synthesis
Manufacturers Pathway	Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-19791-5mg-safety-datasheet.pdf