SGC707

Item no.	HY-19715-100mg
Manufacturer	MedChem Express
CASRN	1687736-54-4
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.08
Formula	C16H18N4O2
Citations	[1]Kaniskan HÜ, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.<br>[2]de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12(1):483.
Smiles	O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1687736-54-4
Available
Product Description	SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	298.34
Clinical_Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Histone Methyltransferase
Isoform	PRMT3
Pathway	Epigenetics

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HY-19715-100mg-safety-datasheet.pdf