G-5555

Item no.	HY-19635-10mM
Manufacturer	MedChem Express
CASRN	1648863-90-4
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.29
Formula	C25H25ClN6O3
Citations	Acta Pharm Sin B. 2020 Apr;10(4):603-614.<br/>Elife. 2017 Mar 13;6:e22207. <br/>Endocr Relat Cancer. 2019 Aug;26(8):699-712. <br/>Exp Hematol. 2023 Sep 21;S0301-472X(23)01701-0.<br/>Research Square Preprint. 2021 Apr.<br/>Endocr Relat Cancer. 2019 Aug;26(8):699-712.<br/>[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.<br/>[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.
Smiles	ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1648863-90-4
Available
Product Description	G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	492.96
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Target	PAK
Manufacturers Target	PAK
Isoform	PAK1; PAK2
Manufacturers Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-19635-10mM-safety-datasheet.pdf