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Upadacitinib

Upadacitinib

Item no.	HY-19569-100mg
Manufacturer	MedChem Express
CASRN	1310726-60-3
Amount	100 mg
Quantity options	100 mg 10g 10mM/1mL 10 mg 1 g 1mg 200 mg 25 mg 500 mg 50 mg 5 g 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C17H19F3N6O
Citations	[1]Nakayamada S, et al. Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis. BioDrugs. 2016 Oct;30(5):407-419.<br/>[2]J. Voss, et al. THU0127 Pharmacodynamics of A Novel JAK1 Selective Inhibitor in Rat Arthritis and Anemia Models and in Healthy Human Subjects. doi 10.1136/annrheumdis-2014-eular.3823.<br/>[3]Parmentier JM, et al. In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2018 Aug 28;2:23.
Smiles	O=C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ABT-494
Available
Product Description	Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	380.37
Clinical Information	Launched
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Target	JAK
Manufacturers Target	JAK
Isoform	JAK1; JAK2; JAK3; Tyk2
Manufacturers Pathway	Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-19569-100mg-safety-datasheet.pdf