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FRAX1036

FRAX1036

Item no.	HY-19538-10mM
Manufacturer	MedChem Express
CASRN	1432908-05-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	98.88
Formula	C28H32ClN7O
Citations	[1]Ong CC, et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res. 2015 Apr 23;17:59.<br/>[2]Mortazavi F, et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. BMC Cancer. 2015 May 9;15:381.
Smiles	O=C1C(C2=CC=C(C3=NC(C)=CN=C3)C=C2Cl)=CC4=CN=C(NCCC5CCN(C)CC5)N=C4N1CC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1432908-05-8
Available
Product Description	FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	518.05
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 5.3 mg/mL (warming)
Target	PAK
Manufacturers Target	PAK
Isoform	PAK1; PAK2; PAK4
Manufacturers Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-19538-10mM-safety-datasheet.pdf