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GSK2018682

GSK2018682

Item no.	HY-19511-10mg
Manufacturer	MedChem Express
CASRN	1034688-30-6
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 25mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.39
Formula	C22H21ClN4O4
Citations	[1]Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.
Smiles	O=C(O)CCCN1C=CC2=C1C=CC=C2C3=NOC(C4=CC(Cl)=C(OC(C)C)N=C4)=N3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1034688-30-6
Available
Product Description	GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	440.88
Clinical Information	Phase 1
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : ≥ 125 mg/mL
Target	LPL Receptor
Manufacturers Target	LPL Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-19511-10mg-safety-datasheet.pdf