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AZD9056 (hydrochloride)

AZD9056 (hydrochloride)

Item no.	HY-19427A-10mM
Manufacturer	MedChem Express
CASRN	345303-91-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.82
Formula	C24H36Cl2N2O2
Citations	Biochim Biophys Acta Mol Basis Dis. 2023 Sep 23;166895.<br>Front Immunol. 2021 Jan 8;11:602016.<br>J Pharmacol Sci. 2020 Sep;144(1):43-51.<br>[1]Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123.<br>[2]Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9.<br>[3]Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932.
Smiles	O=C(C1=CC(CCCNCCCO)=CC=C1Cl)NCC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2.Cl
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	345303-91-5
Available
Product Description	AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	455.46
Clinical_Information	Phase 2
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	P2X Receptor
Isoform	P2X7 Receptor
Pathway	Membrane Transporter/Ion Channel

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-19427A-10mM-safety-datasheet.pdf