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L-685458

L-685458

Manufacturer	MedChem Express
Category	Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	1 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Item no.	HY-19369-1mg
Targets	γ-secretase; Apoptosis
CASRN	292632-98-5
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	L-685,458
Purity	99.37
Product Description	L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	672.85
Clinical_Information	No Development Reported
Manufacturers Research Area	Neurological Disease; Cancer
Solubility	DMSO : 83.3 mg/mL (ultrasonic; warming)
Manufacturers Target	Apoptosis; γ-secretase
Pathway	Apoptosis; Neuronal Signaling; Stem Cell/Wnt

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-19369-1mg-safety-datasheet.pdf