Alda-1

Item no.	HY-18936-5mg
Manufacturer	MedChem Express
CASRN	349438-38-6
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 500 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Microglia Markers
Type	Inhibitors
Specific against	other
Purity	99.99
Formula	C15H11Cl2NO3
Citations	[1]Stachowicz A, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci.<br/>[2]Stachowicz A, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016 Jan;51:144-53.<br/>[3]Ikeda T, et al. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e0128844.<br/>[4]Gomes KM, et al. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015 Jan 20;179:129-138.
Smiles	O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	349438-38-6
Available
Product Description	Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	324.16
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 51 mg/mL
Target	Aldehyde Dehydrogenase (ALDH); Apoptosis
Manufacturers Target	Aldehyde Dehydrogenase (ALDH); Apoptosis
Isoform	ALDH2
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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