SC79

Item no.	HY-18749-100mg
Manufacturer	MedChem Express
CASRN	305834-79-1
Amount	100 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C17H17ClN2O5
Citations	[1]Jo H, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-10586.<br/>[2]So EY, et al. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. BMC Cancer. 2014 Jul 29;14:548<br/>[3]Liu X, et al. Activation of Akt by SC79 decreased cerebral infarct in early cerebral ischemia-reperfusion despite increased BBB disruption. Neurosci Lett. 2018 Aug 10;681:78-82.<br/>[4]Liu W, et al. A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. Am J Pathol. 2018 May;188(5):1171-1182.<br/>[5]Jing ZT, et al. AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G387-G396.<br/>[6]Shuangying Hao, et al. Phosphorylation of Akt by SC79 Prevents Iron Accumulation and Ameliorates Early Brain Injury in a Model of Experimental Subarachnoid Hemorrhage. Molecules. 2016 Mar 10;21(3):325.
Smiles	O=C(OCC)C(C#N)C1C(C(OCC)=O)=C(N)OC2=CC=C(Cl)C=C12
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	305834-79-1
Available
Product Description	SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	364.78
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 50 mg/mL (ultrasonic)
Target	Akt
Manufacturers Target	Akt
Manufacturers Pathway	PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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HY-18749-100mg-safety-datasheet.pdf