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L-NAME (hydrochloride)

L-NAME (hydrochloride)

Item no.	HY-18729A-100mg
Manufacturer	MedChem Express
CASRN	51298-62-5
Amount	100 mg
Quantity options	100 mg 10mM/1mL 500 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.70
Formula	C7H16ClN5O4
Citations	Adv Sci (Weinh). 2024 Apr 3:e2309002.<br>Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1705-1721.<br>Bioengineered. 2022 Jan;13(1):1320-1334.<br>Biomed Pharmacother. 2019 Jul;115:108934. <br>Biomed Pharmacother. 2023 Mar 13;161:114484.<br>Biomed Res Int. 2021 May 15.<br>bioRxiv. 2023 Dec 4.<br>bioRxiv. 2023 Nov 1.<br>Bosn J Basic Med Sci. 2017 May 20;17(2):132-137.<br>Cancer Metab. 2024 May 17;12(1):14.<br>Cancer Res. 2024 Mar 19.<br>Cardiovasc Diabetol. 2024 May 9;23(1):164.<br>Cell Commun Signal. 2021 Mar 18;19(1):35.<br>Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.<br>Exp Ther Med. 2018 Aug;16(2):1079-1086.<br>Front Cardiovasc Med. 2021 Apr 13;8:654254.<br>Front Med. 2021 Apr 13;8:634882.<br>Hum Gene Ther. 2022 Nov 14.<br>Insect Mol Biol. 2024 Jan 5.<br>Int Immunopharmacol. 2023 Dec 21:127:111313.<br>Int J Immunopathol Pharmacol. Jan-Dec 2022;36:3946320221111117.<br>Int J Mol Sci. 2023 Mar 7.<br>J Cell Mol Med. 2024 Apr;28(8):1-11.<br>J Ethnopharmacol. 2022 Jun 17;115476.<br>J Extracell Vesicles. 2023 May;12(5):e12328.<br>JCI Insight. 2021 Sep 22;6(18):e133690.<br>Mediat Inflamm. 2019 Oct 7;2019:6168340.<br>Mediat Inflamm. 2020 Oct 24;2020:1649453.<br>Microvasc Res. 2023 Mar 22;148:104531.<br>Mol Cell Probes. 2023 Feb 2;67:101896.<br>Nutrients. 2022, 14(23), 5025<br>PeerJ. 2023 May 25.<br>Phytomedicine. 6 June 2022, 154242.<br>Placenta. 12 November 2021.<br>Placenta. 2021 Feb 11.<br>Research Square Preprint. 2021 Feb.<br>Research Square Preprint. 2022 May.<br>Research Square Preprint. 2023 May 30.<br>Toxicol Appl Pharmacol. 2019 Mar 1;366:83-95. <br>Vet Microbiol. 19 July 2022, 109514.<br>Biomed Pharmacother. 2020 Aug;128:110240.<br>Cell Tissue Res. 2022 Jan 29.<br>[1]Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40.<br>[2]Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20.<br>[3]Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36.<br>[4]Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973.<br>[5]Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8.<br>[6]V A Peotta, et al. Cardiovascular neural reflexes in L-NAME-induced hypertension in mice. Hypertension. 2001, 38, 3.<br>[7]Xiaofei Li, et al. Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the l-NAME-induced hypertensive rat model. Food Funct. 2016, 7, 5.
Smiles	N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O.[H]Cl
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NG-Nitroarginine methyl ester hydrochloride
Available
Product Description	L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	269.69
Clinical_Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	H2O : 100 mg/mL (ultrasonic)
Manufacturers Target	NO Synthase
Pathway	Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-18729A-100mg-safety-datasheet.pdf