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Erdafitinib

Erdafitinib

Item no.	HY-18708-100mg
Manufacturer	MedChem Express
CASRN	1346242-81-6
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Calcium Binding Protein Markers
Type	Inhibitors
Specific against	other
Purity	99.66
Formula	C25H30N6O2
Citations	[1]Perera TP, et al. Discovery and pharmacological characterization of JNJ-42756493 (erdafitinib), a functionally selective small molecule FGFR family inhibitor. Mol Cancer Ther. 2017 Mar 24. pii: molcanther.0589.2016.
Smiles	CN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	JNJ-42756493
Available
Product Description	Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	446.54
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Target	Apoptosis; FGFR
Manufacturers Target	Apoptosis; FGFR
Isoform	FGFR1; FGFR2; FGFR3; FGFR4
Manufacturers Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-18708-100mg-safety-datasheet.pdf