SIBA

Item no.	HY-18684-10mg
Manufacturer	MedChem Express
CASRN	35899-54-8
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.66
Formula	C14H21N5O3S
Citations	[1]F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16.<br/>[2]B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7.<br/>[3]Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9.
Smiles	O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSCC(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine
Available
Product Description	SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	339.41
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection; Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL
Target	HSV; Nucleoside Antimetabolite/Analog; Parasite
Manufacturers Target	HSV; Nucleoside Antimetabolite/Analog; Parasite
Isoform	HSV-1; Plasmodium
Manufacturers Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-18684-10mg-safety-datasheet.pdf