PP58

Item no.	HY-18622-10mM
Manufacturer	MedChem Express
CASRN	212391-58-7
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.75
Formula	C22H19Cl2N5O2
Citations	[1]Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3(12):1181-93.<br/>[2]Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11(5):691-701.
Smiles	NCCOC1=CC=C(NC(N=C2N3C)=NC=C2C=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PP-58, PP 58
Available
Product Description	PP58 is a pyrido[2, 3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	456.32
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Target	FGFR; PDGFR; Src
Manufacturers Target	FGFR; PDGFR; Src
Isoform	PDGFR
Manufacturers Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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