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CCT241736

CCT241736

Item no.	HY-18161-50mg
Manufacturer	MedChem Express
CASRN	1402709-93-6
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.09
Formula	C22H23Cl2N7
Citations	[1]Bavetsias V, et al. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia. J Med Chem. 2012 Oct 25;55(20):8721-34.
Smiles	CC1=NN(C)C=C1C2=NC3=C(N4CCN(CC5=CC=C(Cl)C=C5)CC4)C(Cl)=CN=C3N2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1402709-93-6
Available
Product Description	CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	456.37
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Aurora Kinase; FLT3
Manufacturers Target	Aurora Kinase; FLT3
Isoform	Aurora A; Aurora B
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-18161-50mg-safety-datasheet.pdf