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Pyrimethamine

Pyrimethamine

Item no.	HY-18062-500mg
Manufacturer	MedChem Express
CASRN	58-14-0
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Food Safety Vitamines Neuroscience Metabolism Diabetes Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.90
Formula	C12H13ClN4
Citations	[1]Aikawa M, et, al. Studies on nuclear division of a malarial parasite under pyrimethamine treatment. J Cell Biol. 1968 Dec;39(3):749-54. [2]Martins-Duarte ÉS, et, al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133(3):294-9.
Smiles	NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Pirimecidan, Pirimetamin, RP 4753
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Antifolate; Parasite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	248.71
Product Description	Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate[1][2].
Manufacturer - Research Area	Infection; Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage
Isoform	Plasmodium
Clinical information	Launched

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HY-18062-500mg-safety-datasheet.pdf