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Zoliflodacin

Zoliflodacin

Item no.	HY-17647-10mM
Manufacturer	MedChem Express
CASRN	1620458-09-4
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.95
Formula	C22H22FN5O7
Citations	[1]Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.
Smiles	O=C(NC(C12[C@]([C@H](C)O[C@H](C)C3)([H])N3C4=C(C=C5C(ON=C5N6C(OC[C@@H]6C)=O)=C4F)C2)=O)NC1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ETX0914; AZD0914
Available
Product Description	Zoliflodacin (ETX0914; AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	487.44
Clinical Information	Phase 3
Manufacturers Research Area	Infection
Solubility	DMSO : 140 mg/mL (ultrasonic)
Target	Antibiotic; Bacterial; DNA/RNA Synthesis
Manufacturers Target	Antibiotic; Bacterial; DNA/RNA Synthesis
Isoform	Quinolone
Manufacturers Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-17647-10mM-safety-datasheet.pdf