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Oteseconazole

Oteseconazole

Item no.	HY-17643-50mg
Manufacturer	MedChem Express
CASRN	1340593-59-0
Amount	50 mg
Quantity options	10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.56
Formula	C23H16F7N5O2
Citations	[1]Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.<br/>[2]Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.
Smiles	O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VT-1161
Similar products	VT-1161
Available
Product Description	Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	527.39
Clinical Information	Launched
Manufacturers Research Area	Infection
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	Cytochrome P450; Fungal
Manufacturers Target	Cytochrome P450; Fungal
Isoform	CYP2C19; CYP2C9; CYP51
Manufacturers Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-17643-50mg-safety-datasheet.pdf