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Closantel

Closantel

Item no.	HY-17596-200mg
Manufacturer	MedChem Express
CASRN	57808-65-8
Amount	200 mg
Quantity options	100 mg 10mM/1mL 200 mg 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.32
Formula	C22H14Cl2I2N2O2
Citations	[1]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.<br>[2]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.
Smiles	O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	57808-65-8
Available
Product Description	Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	663.07
Clinical_Information	No Development Reported
Manufacturers Research Area	Infection
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Parasite
Pathway	Anti-infection

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HY-17596-200mg-safety-datasheet.pdf