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Clarithromycin

Clarithromycin

Item no.	HY-17508-100mg
Manufacturer	MedChem Express
CASRN	81103-11-9
Amount	100 mg
Quantity options	100 mg 10mM/1mL 200 mg 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.90
Formula	C38H69NO13
Citations	[1]D H Peters, et al. Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs. 1992 Jul;44(1):117-64.<br>[2]X J Zhao, et al. An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug Metab Dispos. 1999 Jul;27(7):776-85.<br>[3]Scott J C Stanat, et al. Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel. Mol Cell Biochem. 2003 Dec;254(1-2):1-7.<br>[4]Giulia Petroni, et al. Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K. Cell Death Dis. 2020 Mar 2;11(3):161.<br>[5]S P Klemens, et al. Activity of clarithromycin against <i>Mycobacterium avium</i> complex infection in beige mice. Antimicrob Agents Chemother. 1992 Nov;36(11):2413-7.
Smiles	C[C@@](OC)(C[C@H](C([C@@H]1C)=O)C)[C@@H]([C@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@@H]1O)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	81103-11-9
Available
Product Description	Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[2]. Clarithromycin significantly inhibits the HERG potassium current[3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	747.95336
Clinical_Information	Launched
Manufacturers Research Area	Infection; Cancer
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Manufacturers Target	Antibiotic; Autophagy; Bacterial; Cytochrome P450
Isoform	CYP3; Macrolide
Pathway	Anti-infection; Autophagy; Metabolic Enzyme/Protease

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HY-17508-100mg-safety-datasheet.pdf