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Acyclovir

Acyclovir

Item no.	HY-17422-10mM
Manufacturer	MedChem Express
CASRN	59277-89-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.34
Formula	C8H11N5O3
Citations	[1]Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85.<br/>[2]Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61.<br/>[3]Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7.<br/>[4]Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1(3):139-44.
Smiles	O=C1NC(N)=NC2=C1N=CN2COCCO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Aciclovir; Acycloguanosine
Available
Product Description	Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	225.20
Clinical Information	Launched
Manufacturers Research Area	Cancer; Infection
Solubility	DMSO : ≥ 50 mg/mL
Target	Antibiotic; Apoptosis; Bacterial; HSV
Manufacturers Target	Antibiotic; Apoptosis; Bacterial; HSV
Isoform	HSV-1; HSV-2
Manufacturers Pathway	Anti-infection; Apoptosis
Manufacturers Product type	Reference compound

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HY-17422-10mM-safety-datasheet.pdf