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Dimethyl fumarate

Dimethyl fumarate

Item no.	HY-17363-5g
Manufacturer	MedChem Express
CASRN	624-49-7
Amount	5 g
Quantity options	10mM/1mL 500 mg 5 g
Category	Food Safety Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Signaling Banned Food Additives Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C6H8O4
Citations	[1]Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26.<br>[2]Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25.<br>[3]Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40<br>[4]Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172(15):3929-43.
Smiles	O=C(OC)/C=C/C(OC)=O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	624-49-7
Available
Product Description	Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	144.13
Clinical_Information	Launched
Manufacturers Research Area	Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 41.67 mg/mL (ultrasonic)
Manufacturers Target	Autophagy; Endogenous Metabolite; HIV; Keap1-Nrf2; Reactive Oxygen Species
Pathway	Anti-infection; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-17363-5g-safety-datasheet.pdf