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Dimethyl fumarate

Dimethyl fumarate

Item no.	HY-17363-10mM
Manufacturer	MedChem Express
CASRN	624-49-7
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 500 mg 5 g
Category	Food Safety Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Signaling Banned Food Additives Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C6H8O4
Citations	[1]Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26. [2]Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25. [3]Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40 [4]Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172(15):3929-43.
Smiles	O=C(OC)/C=C/C(OC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	624-49-7
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; Endogenous Metabolite; HIV; Keap1-Nrf2; Reactive Oxygen Species
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	144.13
Product Description	Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[1][2].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 40 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Clinical information	Launched

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HY-17363-10mM-safety-datasheet.pdf