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Suplatast (Tosilate)

Suplatast (Tosilate)

Item no.	HY-17002-10mM
Manufacturer	MedChem Express
CASRN	94055-76-2
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mM/1 mL 500 mg 50 mg
Category	Food Safety Histamines Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.33
Formula	C23H33NO7S2
Citations	[1]Furonaka M, Hattori N, Tanimoto T, Senoo T, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Kohno N. <br>Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. <br>J Pharmacol Exp Ther. 2009 Jan;328(1):55-61.<br/>[2]Yanagihara Y, et, al. Suppression of IgE production by IPD-1151T (suplatast tosilate), a new dimethylsulfonium agent: (2). Regulation of human IgE response. Jpn J Pharmacol. 1993 Jan;61(1):31-9.<br/>[3]Zhao GD, et, al. Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness. Int Arch Allergy Immunol. 2000 Feb;121(2):116-22.<br/>[4]Kurokawa M, et, al. Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 2001 Dec;10(6):333-7.
Smiles	C[S+](C)CCC(NC1=CC=C(C=C1)OCC(COCC)O)=O.CC2=CC=C(C=C2)S(=O)([O-])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	IPD 1151T
Available
Product Description	Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity[1][2][3][4].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	499.64
Clinical Information	Launched
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : ≥ 33 mg/mL\|H2O : ≥ 100 mg/mL
Target	Interleukin Related
Manufacturers Target	Interleukin Related
Isoform	IL-13; IL-2; IL-4; IL-5
Manufacturers Pathway	Immunology/Inflammation
Manufacturers Product type	Reference compound

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HY-17002-10mM-safety-datasheet.pdf