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EHT 1864

EHT 1864

Item no.	HY-16659-10mM
Manufacturer	MedChem Express
CASRN	754240-09-0
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.85
Formula	C25H29Cl2F3N2O4S
Citations	[1]Desire L, et al. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J Biol Chem. 2005 Nov 11;280(45):37516-25.<br/>[2]Shutes A, et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.<br/>[3]Onesto C, et al. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008;439:111-29.<br/>[4]Ying Liu , et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433.
Smiles	O=C1C=C(CN2CCOCC2)OC=C1OCCCCCSC3=CC=NC4=CC(C(F)(F)F)=CC=C34.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	754240-09-0
Available
Product Description	EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG[1][2][3][4].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	581.48
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease; Cancer
Solubility	DMSO : ≥ 32 mg/mL\|H2O : ≥ 100 mg/mL
Target	Ras
Manufacturers Target	Ras
Manufacturers Pathway	GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-16659-10mM-safety-datasheet.pdf