YF-2

Item no.	HY-16531-50mg
Manufacturer	MedChem Express
CASRN	1311423-89-8
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.44
Formula	C20H22ClF3N2O3
Citations	[1]FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.
Smiles	O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1311423-89-8
Available
Product Description	YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	430.85
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer; Neurological Disease
Solubility	DMSO : ≥ 125 mg/mL
Manufacturers Target	Histone Acetyltransferase
Isoform	CBP/p300; GCN5/PCAF
Pathway	Epigenetics

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