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Abemaciclib (methanesulfonate)

Abemaciclib (methanesulfonate)

Item no.	HY-16297-10mg
Manufacturer	MedChem Express
CASRN	1231930-82-7
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 500 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Head & Neck Cancer Brain Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.95
Formula	C28H36F2N8O3S
Citations	Biochem Biophys Rep. 27, September 2021, 101099<br/>Biochem Biophys Res Commun. 2018 Sep 26;504(1):231-237. <br/>Biochem Pharmacol. 2017 Jan 15;124:29-42.<br/>Biochim Biophys Acta. 2017 Nov 20;1865(2):354-363.<br/>bioRxiv. 2020 Jun.<br/>Cancer Res. 2016 Nov 15;76(22):6723-6734. <br/>Cancer Res. 2023 Jun 29;CAN-23-0705.<br/>Cell Death Dis. 2019 Mar 20;10(4):271.<br/>Cell Rep. 2017 Oct 31;21(5):1386-1398.<br/>Cell Rep. 2022 Sep 13;40(11):111331.<br/>Cell. 2018 Nov 1;175(4):984-997.e24.<br/>Clin Cancer Res. 2024 May 8.<br/>EMBO J. 2022 Jan 5;e108946.<br/>Harvard Medical School LINCS LIBRARY<br/>J Exp Clin Cancer Res. 2022 Apr 21;41(1):149.<br/>J Oncol. 2019 Jun 2;2019:5952836. <br/>Mol Cell. 2017 Oct 19;68(2):336-349.e6.<br/>Mol Oncol. 2017 Aug;11(8):1035-1049.<br/>Nat Commun. 2017 Jun 27;8:15916.<br/>Nat Commun. 2019 Jun 28;10(1):2860.<br/>Nature. 2017 Aug 24;548(7668):471-475. <br/>Nutrition. 2019 Apr;60:217-226. <br/>Oncotarget. 2017 Jul 27;8(56):95116-95134. <br/>Oncotarget. 2017 Jun 27;8(40):67422-67438. <br/>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br/>STAR Protocols. 2020 Jun 3;1(1):100024.<br/>ACS Appl Mater Interfaces. 2022 May 11;14(18):20628-20640.<br/>Adv Funct Mater. 2021 Apr 30.<br/>Adv Sci (Weinh). 2020 Aug 4;7(18):2000906.<br/>Adv Sci (Weinh). 2022 Aug 2;e2201834.<br/>Bioact Mater. 8 September 2021.<br/>Biochem Biophys Res Commun. 20 December 2021.<br/>Biomed Chromatogr. 2020 Jun;34(6):e4825.<br/>bioRxiv. 2023 Jan 25.<br/>bioRxiv. 2023 Jul 17.<br/>bioRxiv. 2023 Jul 19.<br/>Blood Cancer J. 2022 Jan 11;12(1):5.<br/>Br J Cancer. 2022 Jan 14.<br/>Breast Cancer Res. 2019 Dec 26;21(1):150.<br/>Cancer Discov. 2023 Dec 4.<br/>Cancer Res. 2017 May 1;77(9):2488-2499.<br/>Cancer Res. 2019 Oct 15;79(20):5245-5259.<br/>Cancer Res. 2022 May 16;82(10):1890-1908.<br/>Cell Chem Biol. 2019 Aug 15;26(8):1067-1080.e8. <br/>Cell Death Dis. 2020 Oct 28;11(10):925.<br/>Cell Rep. 2022 Dec 20;41(12):111826.<br/>Cell. 2023 Jun 8;186(12):2628-2643.e21.<br/>Commun Biol. 2021 Mar 25;4(1):399.<br/>Department of Biochemistry. 2020 Oct.<br/>Eur J Drug Metab Pharmacokinet. 2021 Jul 18;1-11.<br/>Front Oncol. 2021 Jul 13;11:704042.<br/>Fundam Clin Pharmacol. 2021 Feb 1.<br/>Heliyon. 2023 Sep 13.<br/>Int J Biol Sci. 2019 Jan 1;15(3):522-532. <br/>Int J Mol Sci. 2021 Jan 8;22(2):E575.<br/>Int J Mol Sci. 2022 Feb 24;23(5):2493.<br/>J Cell Biochem. 2023 Aug 11.<br/>J Med Chem. 2023 Mar 6.<br/>J Oncol. 2022 Jun 23;2022:8724933.<br/>JCI Insight. 2021 Dec 21;e154402.<br/>Leuk Res. September 2022, 106920.<br/>Nat Commun. 2021 Aug 25;12(1):5112.<br/>Nat Commun. 2021 Nov 16;12(1):6607.<br/>Nat Commun. 2022 Aug 10;13(1):4689.<br/>Nat Metab. 2020 Jan;2(1):41-49.<br/>Nature Cancer. 2021 Apr;2(4):429-443.<br/>Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb 4.<br/>NPJ Precis Oncol. 2021 Mar 19;5(1):20.<br/>Patent. US20200108066A1<br/>R Soc Open Sci. 2019 Jan 23;6(1):181714.<br/>Sci Rep. 2022 Jul 20;12(1):12420.<br/>Sci Rep. 2024 May 8;14(1):10582.<br/>Sci Rep. 2019 Oct 22;9(1):15099. <br/>SSRN. 2022 Nov 21.<br/>SSRN. 2023 Sep 29.<br/>Transl Lung Cancer Res. 2024 May 31;13(5):1032-1046.<br/>University of Gothenburg. 2023 Jun 27.<br/>[1]Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7(12):14803-13.<br/>[2]Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes PLX4032 resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13(10):2253-63.<br/>[3]Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with NSC 613327. Invest New Drugs. 2014 Oct;32(5):825-37.<br/>[4]Wu T, et al. Effect of abemaciclib (LY2835219) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo. Biochem Pharmacol. 2017 Jan 15;124:29-42.
Smiles	CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C.CS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY2835219 (methanesulfonate)
Available
Product Description	Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	602.70
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)\|H2O : 125 mg/mL (ultrasonic)
Target	CDK
Manufacturers Target	CDK
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-16297-10mg-safety-datasheet.pdf