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APTO-253

APTO-253

Manufacturer	MedChem Express
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Item no.	HY-16291-50mg
Targets	MYC, KL
CASRN	916151-99-0
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	LOR-253; LT-253
Purity	98.81
Product Description	APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor[1][2]. APTO-253 has antiarthritic activity[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	367.38
Clinical_Information	Phase 1
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 60 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; c-Myc; KLF
Pathway	Apoptosis; MAPK/ERK Pathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-16291-50mg-safety-datasheet.pdf