Item no. |
HY-16071-10mM |
Manufacturer |
MedChem Express
|
CASRN |
1056901-62-2 |
Amount |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
1 mg
25 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.21 |
Formula |
C17H16ClN3O |
Citations |
[1]Yap TA, et al. AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.<br/>[2]Xi Y, et al. AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-6 |
Smiles |
ClC1=CC=C([C@](C2=CC=C(C3=CNN=C3)C=C2)(O)CN)C=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
1056901-62-2 |
Available |
|
Product Description |
AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC50s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
313.78 |
Clinical Information |
Phase 1 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : 50 mg/mL (ultrasonic) |
Target |
Akt; PKA; Ribosomal S6 Kinase (RSK); ROCK |
Manufacturers Target |
Akt; PKA; Ribosomal S6 Kinase (RSK); ROCK |
Isoform |
Akt1; Akt2; Akt3; p70S6K; PKA; ROCK1; ROCK2 |
Manufacturers Pathway |
Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.