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Arglabin

Arglabin

Item no.	HY-16059-50mg
Manufacturer	MedChem Express
CASRN	84692-91-1
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Neuroscience Neuroinflammation Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.87
Formula	C15H18O3
Citations	[1]Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131(12):1061-1070.<br/>[2]Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198.
Smiles	C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-Arglabin
Available
Product Description	Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene[2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	246.30
Clinical Information	Launched
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : ≥ 100 mg/mL
Target	Autophagy; Farnesyl Transferase; NOD-like Receptor (NLR)
Manufacturers Target	Autophagy; Farnesyl Transferase; NOD-like Receptor (NLR)
Isoform	NLRP3
Manufacturers Pathway	Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-16059-50mg-safety-datasheet.pdf