Item no. |
HY-15996-100mg |
Manufacturer |
MedChem Express
|
CASRN |
1610537-15-9 |
Amount |
100 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.83 |
Formula |
C18H17F4N3O3 |
Citations |
[1]Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
<br> Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7.<br/>[2]Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models.
<br> Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1<br/>[3]Michmerhuizen AR, et al. Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells. Front Endocrinol (Lausanne). 2020 Feb 11;11:35. |
Smiles |
FC(F)OC1=C(OC(F)F)C=C(C=CC([C@](C2=CNN=N2)(C(C)C)O)=C3)C3=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
VT-464 |
Available |
|
Product Description |
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) and an AR antagonist. Seviteronel demonstrates both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
399.34 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : ≥ 50 mg/mL |
Target |
Androgen Receptor; Cytochrome P450 |
Manufacturers Target |
Androgen Receptor; Cytochrome P450 |
Isoform |
CYP17 |
Manufacturers Pathway |
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.