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NVP-CGM097

NVP-CGM097

Item no.	HY-15954-5mg
Manufacturer	MedChem Express
CASRN	1313363-54-0
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	98.06
Formula	C38H47ClN4O4
Citations	[1]Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58
Smiles	ClC(C=C1)=CC=C1[C@@H](C2=CC(OC(C)C)=C(OC)C=C2C3)N(C4=CC=C(N(C[C@@H]5CC[C@@H](N6CC(N(C)CC6)=O)CC5)C)C=C4)C3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CGM097
Available
Product Description	NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	659.26
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	E1/E2/E3 Enzyme; MDM-2/p53
Manufacturers Target	E1/E2/E3 Enzyme; MDM-2/p53
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-15954-5mg-safety-datasheet.pdf