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Ravoxertinib

Ravoxertinib

Item no.	HY-15947-10mg
Manufacturer	MedChem Express
CASRN	1453848-26-4
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.75
Formula	C21H18ClFN6O2
Citations	ACS Comb Sci. 2019 Dec 9;21(12):805-816.<br>Am J Cancer Res. 2020 Nov 1;10(11):3622-3643.<br>Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592.<br>Biochem Biophys Res Commun. 2021 Mar 26;554:63-70.<br>Cancer Cell. 2023 Jul 10;41(7):1345-1362.e9.<br>Cancer. 2020 Mar 15;126(6):1339-1350.<br>Cancers (Basel). 2022 Mar 19;14(6):1575.<br>Cancers (Basel). 2022 May 19;14(10):2493.<br>Cell Death Dis. 2021 Dec 1;12(12):1123.<br>Cell Mol Immunol. 2023 Jan 5.<br>Cell Rep. 2023 Sep 1;42(9):113048.<br>Cell Signal. 2023 Jan 20;110607.<br>Cell. 2018 Sep 20;175(1):186-199.e19.<br>Clin Transl Med. 2023 Aug;13(8):e1381.<br>Diabetes. 2021 Jun 21;db200719.<br>Environ Pollut. 2021 Jan 1;268(Pt B):115748.<br>Exp Mol Pathol. 2021 Feb;118:104587.<br>Gastric Cancer. 2023 Feb 22.<br>Harvard Medical School LINCS LIBRARY<br>Indian J Pharm Sci. 2022.<br>Int J Med Sci. 2022 Jan 1;19(1):195-204.<br>J Cell Biochem. 2020 Mar;121(3):2343-2353.<br>J Cell Mol Med. 2020 Sep;24(17):10151-10165.<br>J Exp Clin Cancer Res. 2023 Jul 13;42(1):166.<br>J Pharmacol Exp Ther. 2020 Jul;374(1):104-112.<br>Methods Mol Biol. 2018;1711:351-398.<br>Mol Oncol. 2020 Nov;14(11):2894-2919.<br>Nat Commun. 2023 Sep 30;14(1):6117.<br>Nat Metab. 2022 Mar;4(3):374-388.<br>Neural Regen Res. 2023.<br>Oncogene. 2021 Jul;40(30):4884-4893.<br>Proteomics. 2023 May 4;e2300041.<br>Redox Biol. 2023 Jul 24, 102825.<br>Reprod Sci. 2020 Feb;27(2):704-712.<br>Sci Transl Med. 2021 Jan 27;13(578):eaba7308.<br>Toxicol In Vitro. 2020 Jun;65:104777.<br>Universität Würzburg. Graduate School of Life Sciences. 2021 Jan.<br>Université de Lausanne. 2024 Feb 7.<br>Zool Res. 2022 Jul 18;43(4):537-551.<br>ACS Omega. 2023 May 23.<br>Nucleic Acids Res. 2022 Apr 8;50(6):3096-3114.<br>Pathol Res Pract. December 2021, 153682.<br>[1]MICHAEL LAI. Opportunity for Pharmaceutical Intervention in Lung Cancer: Selective Inhibition of JAK1/2 to Eliminate EMT-Derived Mesenchymal Cells.<br>[2]Blake JF, et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Developme<br>[3]Kirk Robarge, et al. Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development. Proceedings: AACR Annual Meeting 2014; April 5-9, 2014.
Smiles	O=C1C=C(C2=NC(NC3=CC=NN3C)=NC=C2)C=CN1[C@@H](C4=CC=C(Cl)C(F)=C4)CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GDC-0994
Available
Product Description	Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	440.86
Clinical_Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 35 mg/mL
Manufacturers Target	ERK
Isoform	ERK1; ERK2
Pathway	MAPK/ERK Pathway; Stem Cell/Wnt

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HY-15947-10mg-safety-datasheet.pdf