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GW311616 (hydrochloride)

GW311616 (hydrochloride)

Item no.	HY-15891A-5mg
Manufacturer	MedChem Express
CASRN	197890-44-1
Amount	5 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 1 mg 50 mg 5 mg
Category	Food Safety Proteins Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.84
Formula	C19H32ClN3O4S
Citations	Int Immunopharmacol. 2022 Dec 7;114:109537. J Invest Dermatol. 2020 Jul;140(7):1371-1378.e3. Adv Sci (Weinh). 2023 Jun 22;e2302613. Cell Immunol. 2020 Jun;352:104101. EMBO Rep. 2023 Aug 31;e57032. J Leukoc Biol. 2022 Aug 19. Life Sci. 2020 Feb 1;242:117229. Sci Rep. 2017 Nov 30;7(1):16628. [1]Ohbayashi H,et al. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. [2]Jiang KL, et al. Neutrophil elastase and its therapeutic effect on leukemia cells. Mol Med Rep. 2015 Sep;12(3):4165-4172. [3]Macdonald SJ, et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.
Smiles	O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GW311616A
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Elastase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	433.99
Product Description	GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	H2O : 100 mg/mL (ultrasonic)\|DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-15891A-5mg-safety-datasheet.pdf